Recommended OCALIVA Dosing

Once-Daily, Oral Dosing for OCALIVA1

Drug-to-Drug Interactions1

  • Bile Acid Binding Resins
    Bile acid binding resins such as cholestyramine, colestipol, or colesevelam adsorb and reduce bile acid absorption and may reduce the absorption, systemic exposure, and efficacy of OCALIVA. If taking a bile acid binding resin, take OCALIVA at least 4 hours before or 4 hours after taking the bile acid binding resin, or at as great an interval as possible.
  • Warfarin
    The international normalized ratio (INR) is decreased following co-administration of warfarin and OCALIVA. Monitor INR and adjust the dosage of warfarin, as needed, to maintain the target INR range when co-administering OCALIVA and warfarin.
  • CYP1A2 Substrates With Narrow Therapeutic Index
    OCALIVA may increase the exposure to concomitant drugs that are CYP1A2 substrates. Therapeutic monitoring of CYP1A2 substrates with a narrow therapeutic index (eg, theophylline and tizanidine) is recommended when co-administered with OCALIVA.

ALP, alkaline phosphatase.
 

OCALIVA obeticholic acid OCALIVA obeticholic acid

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Reference:

  1. OCALIVA [package insert]. New York, NY: Intercept Pharmaceuticals, Inc.; 2017.
OCALICA obeticholic acid

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OCALIVA® (obeticholic acid)

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