How OCALIVA Works Differently Than UDCA

OCALIVA Activates FXR to Take PBC Treatment Further1

OCALIVA and UDCA work differently to affect the bile acid pool1-4,a

The OCALIVA® (obeticholic acid) mechanism of action The OCALIVA® (obeticholic acid) mechanism of action

OCALIVA can also be used as monotherapy in patients who are unable to tolerate UDCA1

aHow OCALIVA and UDCA work together in PBC is not entirely understood.

FXR, farnesoid X receptor; PBC, primary biliary cholangitis; UDCA, ursodeoxycholic acid.

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Discover What FXR Can Do

OCALIVA is a potent activator of FXR, a receptor found in the liver and intestines that plays a critical role in bile acid homeostasis.1,2

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OCALIVA obeticholic acid OCALIVA obeticholic acid

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References:

  1. OCALIVA [package insert]. New York, NY: Intercept Pharmaceuticals, Inc.; 2017.
  2. Silveira MG, Lindor KD. Obeticholic acid and budesonide for the treatment of primary biliary cirrhosis. Expert Opin Pharmacother. 2014;15(3):365-372.
  3. URSO [package insert]. Bridgewater, NJ: Aptalis Pharma US, Inc.; 2013.
  4. Paumgartner G, Beuers U. Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited. Hepatology. 2002;36(3):525-531.
OCALICA obeticholic acid

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