OCALIVA Drug-to-Drug Interactions1

Interaction Recommendation
Bile acid binding resins (eg, cholestyramine, colestipol, or colesevelam) adsorb and reduce bile acid absorption and may reduce the absorption, systemic exposure, and efficacy of OCALIVA If taking bile acid binding resins, instruct patients to take OCALIVA at least 4 hours before or 4 hours after (or at as great an interval as possible) taking a bile acid binding resin
International normalized ratio (INR) is decreased following coadministration of warfarin and OCALIVA Monitor INR and adjust the dosage of warfarin, as needed, to maintain target INR range when coadministering OCALIVA and warfarin
OCALIVA may increase exposure to concomitant drugs that are CYP1A2 substrates with a narrow therapeutic index (eg, theophylline and tizanidine) Therapeutic monitoring of CYP1A2 substrates with a narrow therapeutic index (eg, theophylline and tizanidine) is recommended when coadministered with OCALIVA
OCALIVA obeticholic acid OCALIVA obeticholic acid

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Reference:

  1. OCALIVA [package insert]. New York, NY: Intercept Pharmaceuticals, Inc.; 2017.
OCALICA obeticholic acid

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OCALIVA® (obeticholic acid)

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