About the Farnesoid X Receptor (FXR)

FXR Is a Key Regulator of Bile Acid, Inflammatory, Fibrotic, and Metabolic Pathways1

FXR Plays a Critical Role in Bile Acid Homeostasis2,3

  • The farnesoid X receptor (FXR) is primarily located in tissues that are integral to bile acid metabolism, including the liver and intestines1,2
  • Activation of FXR has anticholestatic effects, preventing the toxic buildup of bile acid in the liver1,2,4
FXR graphicFXR graphic

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References:

  1. OCALIVA [package insert]. New York, NY: Intercept Pharmaceuticals, Inc.; 2017.
  2. Silveira MG, Lindor KD. Obeticholic acid and budesonide for the treatment of primary biliary cirrhosis. Expert Opin Pharmacother. 2014;15(3):365-372.
  3. Ding L, Yang L, Wang Z, Huang W. Bile acid nuclear receptor FXR and digestive system diseases. Acta Pharm Sin B. 2015;5(2):135-144.
  4. Purohit T, Cappell MS. Primary biliary cirrhosis: pathophysiology, clinical presentation and therapy. World J Hepatol. 2015;7(7):926-941.
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